Streptococcus pneumonia infection in children

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Objectives	Estimate the impact of PCV on IPD (includes meningitis, pneumonia with fever, pleural effusion/empyema, peritonitis and sepsis) among children 1-35 months of age in India. Quantify the change in the proportion of IPD caused by vaccine-type serotypes in the pre-PCV period compared with the post-PCV period in Indian states that have introduced PCV during the study period. Monitor Streptococcus pneumoniae antimicrobial susceptibility trends among children 1- 35 months with IPD in the pre-PCV period compared with the post-PCV period in India. Monitor secular trends of IPD strains in Indian states that have made no decision to introduce PCV and compare changes in IPD in states that introduced PCV during the study period. Pneumonia in Indian context undertaken by Indian Investigator Quantify the change in the proportion of hospitalized pneumonia cases among children 1- 35 months carrying a vaccine-type pneumococcus in the nasopharynx inthe pre-PCV period compared with that in the post-PCV period. Quantify the change in the proportion of community children aged 1-59 months who are colonized with a vaccine serotype pneumococcus from the pre-PCV period to the post-PCV period, as a measure of overall PCV program impact on pneumococcal carriage in this population. Determine the overall economic impact of PCV on: Household and societal costs of hospitalized pneumonia and IPD among children 1-59 months of age, comparing the pre-PCV and post-PCV periods. The proportion of households with a child admitted with pneumonia or other IPD facing catastrophic payments from out-of-pocket health expenses and total expenses, comparing the pre-PCV and post-PCV periods. The return on investment of PCV for the Indian government based on the PCV rollout program in selected states Laboratory surveillance of Streptococcus pneumoniae isolated from sterile body fluids at BASIS sites where decision regarding PCV introduction is yet to be taken
Timeline	Apr 2018 to Mar 2022
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Methods
Expected Outcomes

Principal Investigator

Dr. N. K Arora

Co-PI’s

Implementation Team

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